SkinEthic™ RHE Human Epidermis
Normal human keratinocytes cultured at the air-liquid interface on an inert polycarbonate filter in a chemically defined medium — a reconstructed human epidermis.
Global Partner
EPISKIN
World leader in tissue engineering.
EPISKIN, world leader in tissue engineering, offers Human Reconstructed Tissues to the global scientific community – academic and industry – to support research and development activities in Safety and Efficacy.
Featured Products
T-Skin™ Human Full Thickness Model
Reconstructed skin with a dermal equivalent of human fibroblasts under a stratified, well-differentiated epidermis from normal human keratinocytes.
SkinEthic™ HCE Corneal Epithelium
Immortalized human corneal epithelial cells reconstructing a corneal epithelial tissue at the air-liquid interface — used for the OECD TG492 eye irritation test.
SkinEthic™ RHPE Pigmented Epidermis
Keratinocytes co-cultured with melanocytes of phototypes II, IV and VI, forming 3D pigmented epidermal tissue for pigmentation studies.
What We Supply
Reconstructed Tissue Models
Tissue Models
10
01
T-Skin
Browse catalog
02
SkinEthic RHE
Browse catalog
03
RHE-LC
Browse catalog
04
RHPE (Pigmented Epidermis)
Browse catalog
05
HCE (Corneal Epithelium)
Browse catalog
06
HO2E (Oesophageal Epithelium)
Browse catalog
07
HOE (Oral Epithelium)
Browse catalog
08
HGE (Gingival Epithelium)
Browse catalog
09
HBE (Bladder Epithelium)
Browse catalog
10
HVE (Vaginal Epithelium)
Browse catalog
Explore
Models & Applications
Models & Applications
12
01
Bacterial Adhesion
Learn more
02
Skin Corrosion
Learn more
03
UV Exposure
Learn more
04
DNA Damage
Learn more
05
Permeability
Learn more
06
Medical Devices
Learn more
07
Omics
Learn more
08
Skin Immune Response
Learn more
09
Depigmentation
Learn more
10
Oesophageal irritation
Learn more
11
Bladder irritation
Learn more
12
Vaginal irritation
Learn more
About the Partner
More About EPISKIN
We provide our worldwide clients reliable and relevant in vitro tools for safety and efficacy evaluation. Based on easy-to-use and validated protocols, EPISKIN tissue models allow industrial corporations to screen and measure with high precision, the irritation, penetration, metabolism, or efficacy of large number of formulations or actives.
EPISKIN Corporate Movie — Advanced 3D models for a better, more predictive and more ethical science
Our product lines include: reconstructed human epidermis; reconstructed human epidermis with melanocytes (different complexions are available from phototype II to VI); reconstructed human dermis and epidermis (Full Thickness Model); Reconstructed Human Corneal Epithelium; reconstructed human mucosa: Oral, Gingival and Vaginal Epithelium.
All of these models allow the evaluation of raw materials, active ingredients and finished products being either in a solid, liquid, powder, cream or gel form.
Industrialised Tissue Production
A unique cell culture process industrializes reconstructed human tissue production, delivering thousands of tissues every week.
Cosmetic, Pharma & Chemical Partners
EPISKIN partners with cosmetic, pharmaceutical and chemical industries for safety and efficacy testing.
Stringent Batch QC
Each tissue batch undergoes stringent quality control for viability, morphology, and barrier function, in compliance with OECD and regulatory standards.
Animal-Free Models
Developed from ethically sourced human keratinocytes and animal-free, eliminating the need for animal testing.
Validated & Certified
Applications & Certifications
- ISO 9001 (since 1999)
- OECD Validated
- Bacterial Adhesion
- Skin Corrosion
- UV Exposure
- DNA Damage
- Permeability
- Medical Devices
- Omics
- Skin Immune Response
- Depigmentation
- Oesophageal Irritation
- Bladder Irritation
- Vaginal Irritation
Also from Krishgen
Learn More
A Comprehensive Array of Multifunctional Cosmetic Claims
Eye Care, Cosmetic & Herbal Soaps, Skin Care, Hair Care & more
Downloads
Catalog & Flyers
Resources
Scientific References
Scientific References
4
01
Demonstrating the principal mechanism of action of medical devices intended for vaginal use on reconstructed human vaginal epithelium: the case of two hyaluronic acid-containing devices
Read more
02
Evaluation of Antimicrobial, Antiadhesive and Co-Aggregation Activity of a Multi-Strain Probiotic Composition against Different Urogenital Pathogens
Read more
03
Use of reconstructed skin model to assess the photoprotection afforded by three sunscreen products having different SPF values against DNA lesions and cellular alterations
Read more
04
Evaluation of Human Esophageal Epithelium Permeability in Presence of Different Formulations Containing Hyaluronic Acid and Chondroitin Sulphate
Read more
FAQ
Frequently Asked Questions
What 3D reconstructed human tissue models does Episkin offer?
Skin irritation, corrosion, phototoxicity, and ocular irritation models.
Are Episkin models OECD validated?
Yes. Episkin models comply with OECD guidelines and are widely accepted for regulatory testing.
What are the lead times for ordering Episkin tissue models in India?
Standard lead time 4–5 weeks due to production and international shipping constraints.
How are Episkin products shipped?
Temperature-controlled express shipping with detailed handling instructions on arrival.
How does EPISKIN ensure the quality and reproducibility of its tissue models?
Each EPISKIN tissue batch undergoes stringent quality control for viability, morphology, and barrier function. This ensures consistent, reliable performance and full compliance with OECD and regulatory standards.
What applications can EPISKIN tissue models be used for?
EPISKIN models are used in cosmetics, pharmaceuticals, chemicals, and academic research to evaluate skin irritation, corrosion, phototoxicity, genotoxicity, and compound penetration or efficacy.
What are the storage and handling requirements for EPISKIN models?
Upon arrival, tissues must be stored at 37°C in a CO₂ incubator and used immediately according to the test protocol provided. They are shipped ready-to-use and should not be frozen.
Do EPISKIN models require ethical clearance for testing?
No. EPISKIN models are developed from ethically sourced human keratinocytes and are animal-free, eliminating the need for animal testing or related ethical approvals.
Can EPISKIN provide customized testing services or model adaptations?
Yes. EPISKIN offers customized models and testing solutions upon request, including pigmentation, atopic, and reconstructed ocular tissues tailored for specific study needs.