Role of UDP-Glucuronosyltransferases in Drug Metabolism and Drug-Drug Interactions
The importance of glucuronidation for metabolism of xenobiotics in humans is shown by the abundance and broad tissue distribution of UGT enzymes, the diversity of substrates and reactions catalyzed, and their genetic polymorphisms. The involvement of UGTs in metabolism of new drug candidates is presented from regulatory and safety perspectives.
The session reviews basic biochemical characteristics of UGTs and major glucuronides formed in humans, highlights acyl-glucuronides and their significance for drug-drug interactions, and covers why UGTs’ in vivo contributions are underpredicted — and laboratory approaches to improve those predictions.
Key Learning Objectives
- Significance of UGT-mediated metabolism in the drug development process
- Consequences of acyl-glucuronide formation
- Underprediction of in vivo UGT-mediated metabolism
Watch Now: Role of UDP-Glucuronosyltransferases in Drug Metabolism and Drug-Drug Interactions
This webinar is available on demand. Fill in the form to watch the full recording — we'll email you the link too.
- October 5, 2021
- kbiinfo@krishgen.com
- +91 22 49198700
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